BACE2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA513103
DescriptionBACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
|PBS with 0.09% sodium azide|
|KLH conjugated synthetic peptide between 310-339 amino acids from the C-terminal region of human BACE2C|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Immunohistochemistry, Western Blot|
|-20° C, Avoid Freeze/Thaw Cycles|
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