BAG-1 Mouse anti-Human, Unlabeled, Clone: 19, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611868
Members of the Bcl-2 protein family function to inhibit (Bcl-2, Bcl-XL, Mcl-1, A1) or promote (Bax, Bak, Bcl-Ls, Bad, Bid, Bim, Bik) apoptosis. Bcl-2- associated athanogene-1 (BAG-1) was identified through its interaction with Bcl-2 family proteins. BAG-1 protein has been reported to be expressed as at least three isoforms, 50 kDa (BAG-1L), 46 kDa (BAG-1M/RAP46), and 33 kDa (BAG-1S), which contain conserved C-terminal regions that have an Hsp70-binding domain (HBD). BAG-1M was also identified as RAP46, a protein that binds steroid hormone receptors. BAG1-M is transported to the nucleus along with the ligand-bound glucocorticoid receptor (GR), where it downregulates GR binding to DNA in an Hsp70-dependent manner. In the Hsp70-Hip chaperone system, BAG-1M/RAP46 acts as a negative regulator of Hsp70 chaperone activity, while in the Hsc70-dj systems, BAG-1 acts as a positive cochaperone. BAG-1 mRNA is ubquitously expressed in cells and tissues, while BAG-1L protein is preferentially expressed in many tumor cell lines. Thus, BAG-1 isoforms are multifunctional proteins that may be involved in protein folding, hormone receptor signaling, and malignant transformation.
|Human BAG-1 aa. 155-258|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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