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BARD1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524160

Catalog No. PIPA524160

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

BARD1 is a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and domit protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
Specifications

Specifications

BARD1
Polyclonal
PBS with 0.09% sodium azide
Q99728
BARD-1, BRCA1 associated RING domain 1 isoform alfa, BRCA1 associated RING domain 1 isoform beta, BRCA1 associated RING domain 1 isoform delta, BRCA1 associated RING domain 1 isoform epsilon, BRCA1 associated RING domain 1 isoform eta, BRCA1 associated RING dom
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
580
Western Blot
Unconjugated
BARD1
Liquid
BARD1
KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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