BARD1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA524160
DescriptionBARD1 is a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and domit protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
|PBS with 0.09% sodium azide|
|BARD-1, BRCA1 associated RING domain 1 isoform alfa, BRCA1 associated RING domain 1 isoform beta, BRCA1 associated RING domain 1 isoform delta, BRCA1 associated RING domain 1 isoform epsilon, BRCA1 associated RING domain 1 isoform eta, BRCA1 associated RING dom|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1|
|Antigen affinity chromatography|
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