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Bax Sheep anti-Mouse, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA112602

Catalog No. 01-674-802


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Description

Description

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3 ft. UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.
Specifications

Specifications

Bax
Polyclonal
PBS with 0.08% sodium azide
Q07813
Bax zeta
Sheep
IgG
250 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12028
Immunoprecipitation, Western Blot
Unconjugated
Bax
Liquid
BAX
Synthetic peptide corresponding to residues 172 to 199 of Bax.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Mouse
Documents
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