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BCAS3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520906

Catalog No. PIPA520906


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Description

Description

A suggested positive control is rat brain tissue lysate. PA5-20906 can be used with blocking peptide PEP-1020.

The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.
Specifications

Specifications

BCAS3
Polyclonal
Unconjugated
BCAS3
Liquid
BCAS3
An 18 amino acid peptide near the amino terminus of human BCAS3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9H6U6, Q8CCN5
GAOB1, MAAB; BCAS4/BCAS3 fusion; breast carcinoma amplified sequence 4/3 fusion protein; breast carcinoma-amplified sequence 3; metastasis associated antigen of breast cancer; protein Maab1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
192197, 363662, 54828
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