BRCA2 and CDKN1A interacting protein, Mouse, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a full-length human BCCIP protein.

Manufacturer:  Abnova Corporation H00056647B01

Catalog No. 89-007-933

Description

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq

Sequence: MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAEKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV

Specifications

• Antigen: BRCA2 and CDKN1A interacting protein
• Conjugate: Unconjugated
• Formulation: No additive
• Gene Accession No.: BC009771
• Gene Alias: TOK-1|TOK1
• Host Species: Mouse
• Quantity: 50 uL
• Research Discipline: Cell Cycle
• Whole Molecule: Y
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: Immunofluorescence, Western Blot
• Description: Mouse polyclonal antibody raised against a full-length human BCCIP protein.
• Gene: BCCIP
• Format: Serum
• Gene Symbols: BCCIP
• Immunogen: BCCIP (AAH09771, 1 a.a. ~ 314 a.a) full-length human protein.
• Regulatory Status: RUO
• Storage Requirements: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Primary or Secondary: Primary
• Gene ID (Entrez): 56647