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BRCA2 and CDKN1A interacting protein, Mouse, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a full-length human BCCIP protein.

Manufacturer:  Abnova Corporation H00056647B01

Catalog No. 89-007-933


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Description

Description

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq

Sequence: MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAEKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV
Specifications

Specifications

BRCA2 and CDKN1A interacting protein
Polyclonal
Mouse polyclonal antibody raised against a full-length human BCCIP protein.
BCCIP
TOK-1/TOK1
Mouse
50 μL
Cell Cycle
Primary
Human
Immunofluorescence, Western Blot
Unconjugated
No additive
BC009771
BCCIP
BCCIP (AAH09771, 1 a.a. ∼ 314 a.a) full-length human protein.
RUO
Yes
56647
Serum
Safety and Handling

Safety and Handling

SDS
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Product Certifications
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