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Bcl-2 Mouse anti-Mouse, Rat, Clone: 10C4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112246

Catalog No. 01-670-946


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Description

Description

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

BCL-2
Monoclonal
Unconjugated
Bcl2
Liquid
BCL2
Synthetic peptide corresponding to residues 61-76 of mouse bcl-2.
Protein A/G
RUO
Antibody
Monoclonal
Mouse, Rat
Western Blot
10C4
PBS with 0.08% sodium azide
P49950, P10417
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12043, 24224
Documents
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