Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Bcl-2 Sheep anti-Canine, Human, Rat, Polyclonal, Invitrogen™

Sheep Polyclonal Antibody

Manufacturer:  Invitrogen PA128275

Catalog No. PA128275


Add to cart

Description

Description

PA1-28275 detects Bcl2 from rat, canine, and human samples. PA1-28275 has been successfully used in immunofluorescence, immunoprecipitation, and Western blot applications. A predicted molecular weight of approximately 29 kDa is expected. The PA1-28275 immunogen is a proprietary sequence. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

BCL-2
Polyclonal
Unconjugated
BCL2
Liquid
BCL2
Proprietary sequence
Protein G
RUO
Antibody
Polyclonal
Canine, Human, Rat
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
1 mg/mL
PBS with 0.08% sodium azide
Q6R755, P10415, P49950
Bcl-2
Sheep
IgG
125 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
24224, 403416, 596
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit