Bcl-2 Sheep anti-Canine, Human, Rat, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA128275
PA1-28275 detects Bcl2 from rat, canine, and human samples. PA1-28275 has been successfully used in immunofluorescence, immunoprecipitation, and Western blot applications. A predicted molecular weight of approximately 29 kDa is expected. The PA1-28275 immunogen is a proprietary sequence. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
|Canine, Human, Rat|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|PBS with 0.08% sodium azide|
|Q6R755, P10415, P49950|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|24224, 403416, 596|
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