Bcl-2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA130411
PA1-30411 detects Bcl2 from rat, human, mouse samples. PA1-30411 has been successfully used in immunohistochemistry (frozen tissue), immunoprecipitation, and Western blot applications. Suggested positive controls for this product are HL-60 and Jurkat. The PA1-30411 immunogen is a Synthetic peptide (Human) (N terminal).BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
|Synthetic peptide (Human) (N terminal).|
|Human, Mouse, Rat|
|Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot|
|PBS with 0.2% gelatin and 0.1% sodium azide|
|P10415, P10417, P49950|
|4° C, do not freeze|
|12043, 24224, 596|
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