Bcl-B Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520234
Despite its predicted molecular weight, Bcl-B often migrates at higher molecular weights, presumably due to post-translational modifications. A suggested positive control is Jurkat cell lysate. PA5-20234 can be used with blocking peptide PEP-0353.Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predomitly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1.
|A 16 amino acid peptide from near the amino terminus of human Bcl-B.|
|Antigen affinity chromatography|
|Immunocytochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|BCL-B, Boo, Diva; anti-apoptotic protein NrH; apoptosis regulator Bcl-B; bcl-2-like protein 10; bcl2-L-10|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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