MilliporeSigma anti-Bcl-xL (Ab-1) (201-216), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC67100UG
Specifically detects Bcl-xL (201-216) Clone: in Human, Mouse, Opossum, Rat samples, and it is validated for Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immuno Blottingbcl-x is abcl-2-related gene that can function as a regulator of programmed cell death (apoptosis) independent ofbcl-2. Alternative splicing results in two distinct bcl-x mRNAs, bcl-xL and bcl-xS. The larger mRNA gives rise to a protein product, bcl-xL, which is similar in size and predicted structure tobcl-2. bcl-x immunoreactivity has been detected in a wide variety of cell types and the protein is typically present in the cytosol in association with the mitochondrial periphery, a property shared withbcl-2. Of the two isoforms of bcl-x, the long (bcl-xL) is the most abundant mRNA species expressed in embryonic and adult tissues and most likely differs frombcl-2 in its regulatory activity on cell differentiation through controlled tissue specific expression. Like its homologbcl-2, the mechanism and extent of bcl-x's function are still increasing. bcl-xL has been shown to modify the cell's response to oxidants as well as to participate in resistance to chemotherapeutic agents and radiation.
|a synthetic peptide (PWIQENGGWDTFVELY) corresponding to amino acids 201-216 of human Bcl-x|
|2°C to 8°C|
|Human, Murine, Opossum, Rat|
|Immuno Blotting, Immunoblot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|In 50mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.|
|Recognizes the ∽28kDa Bcl-x protein in doxorubicin-treated MCF-7 cells.|
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