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Bcl-xL Mouse anti-Human, Clone: 7D9, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA137167

Catalog No. 01-671-679

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with mouse based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is Hodgkin ft.s lymphoma.

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Specifications

Specifications

BCL-XL
Monoclonal
Unconjugated
BCL2L1
Liquid
BCL2L1
Synthetic peptide corresponding to N-terminus of mouse BCL-XL protein
Protein A/G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin)
7D9
TBS with 1% BSA and <0.1% sodium azide; pH 7.6
Q07817
BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS
Mouse
IgG2a
7 mL
4° C, do not freeze
Primary
598
Documents
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