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Bcl-xL Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA137161

Catalog No. 01-673-115


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is colon carcinoma.

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Specifications

Specifications

BCL-XL
Polyclonal
PBS with 1% BSA and 0.099% sodium azide; pH 7.6
Q07817
BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS, apoptosis regulator Bcl-X, bcl-2-like protein 1, protein phosphatase 1, regulatory subunit 52
Rabbit
IgG
1 mL
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Primary
598
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
BCL2L1
Liquid
BCL2L1
Synthetic peptide derived from the N-terminus of human Bcl-x protein
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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