Bcl-xL Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141101
This antibody is predicted to react with mouse based on sequence homology. Suggested positive control: antigen standard for BCL2L1 (transient overexpression lysate), Jurkat, MOLT-4, or Rh-30.BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
|Synthetic peptide corresponding to residues 3-14 of human and mouse Bcl-XL and Bcl-XS.|
|PBS with 0.02% sodium azide|
|BCL-XL/S, BCL2L, BCLX, Bcl-X, DKFZp781P2092, bcl-xL, bcl-xS|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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