Bcl-10 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528946
PA5-28946 targets BCL10 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-28946 immunogen is recombit fragment corresponding to a region within amino acids 1 and 233 of Human BCL10. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
|Recombit fragment corresponding to a region within amino acids 1 and 233 of Human BCL10|
|Antigen affinity chromatography|
|ChIP assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|CARMEN, CIPER, CLAP, c-E10, mE10, B-cell lymphoma/leukemia 10, CARD containing molecule enhancing NF-kB, CARD-containing apoptotic signaling protein, CARD-containing molecule enhancing NF-kappa-B, CARD-containing proapoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, cCARMEN|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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