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Bcl-2 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527094

Catalog No. PIPA527094


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Description

Description

PA5-27094 targets BCL2 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27094 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 48 of Human BCL2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
Specifications

Specifications

Bcl-2
Polyclonal
Unconjugated
BCL2
Liquid
BCL2
Synthetic peptide corresponding to a region within amino acids 1 and 48 of Human BCL2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Immunohistochemistry (Paraffin), Western Blot
0.48 mg/mL
PBS with 1% BSA, 20% glycerol and 0.025% Proclin 300; pH 7
P10415, P49950
Bcl-2, PPP1R50, apoptosis regulator Bcl-2, protein phosphatase 1, regulatory subunit 50
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
24224, 596
Documents
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