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BCLAF1 Rabbit anti-Canine, Human, Mouse, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141680

Catalog No. 01-675-087


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Description

Description

PA1-41680 detects BCLAF1 in chimpanzee, canine, human and mouse samples. This antibody is expected to react with chicken and mosquito samples based on sequence homology.

BCLAF1 is an intracellular, death promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bzip) and MYB DNA binding domains. From recent research it can be concluded that in case of apoptotic cells this protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope. When over expressed this protein induces apoptosis and can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal, potentially helpful to overcome the resistance to STI571. BCLAF1 is found to express mostly in skeletal muscles.
Specifications

Specifications

BCLAF1
Polyclonal
Unconjugated
BCLAF1
Liquid
BCLAF1
Synthetic peptide corresponding to residues 700-750 of human BCLAF1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9NYF8, Q8K019
bK211L9.1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
483999, 72567, 9774
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