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BCR Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA529334

Catalog No. PIPA529334


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Description

Description

PA5-29334 targets Bcr in IHC (P), and WB applications and shows reactivity with Human samples. The PA5-29334 immunogen is recombit fragment corresponding to a region within amino acids 907 and 1231 of Human Bcr. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Bcr
Polyclonal
Unconjugated
BCR
Liquid
BCR
Recombit fragment corresponding to a region within amino acids 907 and 1231 of Human Bcr
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P11274
ALL, BCR1, CML, D22S11, D22S662, PHL, breakpoint cluster region protein, renal carcinoma antigen NY-REN-26
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
613
Documents
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