anti-BDNF Polyclonal, Thermo Scientific™

BDNF Polyclonal Ab PA1-18371 from Thermo Scientific™ specifically detects BDNF in Hu and Rt samples, and it is validated for ELISA, IHC and WB

Manufacturer: Invitrogen PA118372

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Catalog No. 01-670-624

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    Specifications

    Antigen BDNF
    Applications Enzyme Linked Immunosorbent Assay,Immunohistochemistry,Western Blot
    Conjugate Unlabeled
    Cross Reactivity Human,Rat
    Format Purified
    Formulation 500μg purified antibody (1mg/mL) and no preservative
    Gene Accession No. P23363, P23560
    Gene Alias Brain-derived neurotrophic factor, Abrineurin
    Gene Symbols BDNF
    Host Species Rabbit
    Immunogen Synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF.
    Isotype IgG
    Quantity 500μg
    Species Reactivity Human, Rat
    Storage Requirements Avoid Freeze/Thaw Cycles
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 24225, 627

    BDNF Polyclonal Ab PA1-18371 from Thermo Scientific™ specifically detects BDNF in Hu and Rt samples, and it is validated for ELISA, IHC and WB

    BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
    Host Species: Rabbit
    Cross Reactivity: Human, Rat
    Isotype: IgG
    Immunogen: Synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF.
    Formulation: 500µg purified antibody (1mg/mL) and no preservative
    Synonyms: Brain-derived neurotrophic factor, Abrineurin
    Uniprot Accession: P23363, P23560
    Entrez GeneID: 24225, 627
    Gene Symbol: BDNF
    PA1-18372 detects BDNF from human and rat samples. This antibody cross-reacts with mouse NGF, recombinant human NT3, and NT4/5. PA1-18372 has been successfully used in immunohistochemistry, ELISA, and Western blot procedures. The PA1-18372 immunogen is a synthetic peptide corresponding to residues H(129) S D P A R R G E L(138) of human BDNF, conjugated to KLH. Reconstitute with 500 ul of distilled water.

  • Description & Specifications

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