anti-BDNF Polyclonal, Thermo Scientific™

BDNF Polyclonal Ab PA1-18357 from Thermo Scientific™ specifically detects BDNF in Hu, Ms and Rt samples, and it is validated for ELISA, IHC, Inhibition Assays and WB

Manufacturer: Thermo Scientific PA118370

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Catalog No. 01-670-622

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    Specifications

    Antigen BDNF
    Applications ELISA,Immunohistochemistry
    Conjugate Unlabeled
    Cross Reactivity Human,Rat
    Format Purified
    Formulation 20μg purified Antibody (1mg/mL) no preservative;
    Gene Accession No. P21237, P23363, P23560
    Gene Alias Brain-derived neurotrophic factor, Abrineurin
    Gene Symbols BDNF
    Host Species Rabbit
    Immunogen A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
    Isotype IgG
    Quantity 20μg
    Species Reactivity Human, Mouse, Rat
    Storage Requirements avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 12064, 24225, 627

    BDNF Polyclonal Ab PA1-18357 from Thermo Scientific™ specifically detects BDNF in Hu, Ms and Rt samples, and it is validated for ELISA, IHC, Inhibition Assays and WB

    BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
    Host Species: Rabbit
    Cross Reactivity: Human, Mouse, Rat
    Isotype: IgG
    Immunogen: A synthetic peptide corresponding to human BDNF protein aa 129-138 (HSDPARRGEL) conjugated to KLH
    Formulation: 20µg Purified Antibody (1mg/ml) in Antibody, with no preservative
    Synonyms: Brain-derived neurotrophic factor, Abrineurin
    Uniprot Accession: P21237, P23363, P23560
    Entrez GeneID: 12064, 24225, 627
    Gene Symbol: BDNF
    The immunogenic sequence is highly conserved among most mammalian species. This antibody exhibits less than 0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 by dot blot analysis. Reconstitute with 20 ul of distilled water.

  • Description & Specifications

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