BDNF Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA128301
PA1-28301 detects BDNF from human samples. PA1-28301 has been successfully used in Western blot applications. The PA1-28301 immunogen is: Recombit fragment (Human). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer ft.s and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
|Recombit fragment (Human).|
|Antigen affinity chromatography|
|PBS with 1% BSA, 50% glycerol and 0.02% thimerosal; pH 7.2|
|Brain-derived neurotrophic factor, Abrineurin|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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