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BDNF Chicken anti-Human, Mouse, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA19522

Catalog No. 01-674-405


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Description

Description

PA1-9522 detects BDNF in human and mouse samples. PA1-9522 has been successfully used in ELISA procedures. PA1-9522 immunogen is two peptides from human BDNF that were mixed

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer ft.s and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
Specifications

Specifications

BDNF
Polyclonal
Unconjugated
BDNF
Liquid
BDNF
To peptides from human BDNF that were mixed
IgY fraction
RUO
Antibody
Polyclonal
Human, Mouse
ELISA
1 mg/mL
PBS with 0.02% sodium azide
P23560, P21237
Brain-derived neurotrophic factor, Abrineurin
Chicken
IgY
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
12064, 627
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