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beta-1 Adrenergic Receptor Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1049

Catalog No. PIPA1049


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Description

Description

PA1-049 detects beta-1 adrenergic receptor (B1AR) from , human, mouse, non-human primate, and rat tissues. PA1-049 has been successfully used in Western blot and immunofluorescence procedures. By Western blot, this antibody detects an ~50.5 kDa band representing B1AR in mouse kidney membrane preparation. Immunofluorescence staining of B1AR in mouse kidney distal tubule with PA1-049 yields a pattern consistent with plasma membrane staining. The PA1-049 immunogen is a synthetic peptide corresponding to residues H(394) G D R P R A S G C L A R A G(408) of mouse B1AR. This sequence is completely conserved between mouse and rat B1AR.

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintece of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. BARs participate in diverse processes including development, behavior, cardiac function, smooth muscle tone, and metabolism. In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. Other studies have shown that the direct regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine sensitive-adenylyl cyclase system. Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines.
Specifications

Specifications

beta-1 Adrenergic Receptor
Polyclonal
whole serum with 0.05% sodium azide
P08588, P34971, P18090
Beta-1 adrenoceptor, Beta-1 adrenoreceptor, ADRB1
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Non-human primate, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
ADRB1
Liquid
ADRB1
Synthetic peptide corresponding to residues H(394) G D R P R A S G C L A R A G(408) of mouse B1AR.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
11554, 153, 24925
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