beta-2 Microglobulin Mouse anti-Human, Porcine, Clone: B2M-02, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119413
This antibody reacts with beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin.Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predomitly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
|PBS with 15mM sodium azide; pH 7.4|
|Orla-B2m, B2M, Beta 2 microglobulin precursor, Beta chain of mhc class 1 proteins, Hdcma22p|
|4° C, do not freeze|
|ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot|
|Purified isolated human beta- 2 microglobulin.|
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