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beta-2 Microglobulin Mouse anti-Human, HRP, Clone: B2M-01, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119679

Catalog No. 01-676-706


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Description

Description

This antibody reacts with beta2-microglobulin associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. It will not cross-react with mouse, rabbit, canine, chicken or bovine.

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predomitly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
Specifications

Specifications

beta-2 Microglobulin
Monoclonal
1 mg/mL
PBS with 1% BSA and 0.01% thimerosal
P61769
Orla-B2m, B2M, Beta 2 microglobulin precursor, Beta chain of mhc class 1 proteins, Hdcma22p
Mouse
IgG2a
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
567
Western Blot
B2M-01
HRP
B2M
Liquid
B2M
Purified human beta- 2 microglobulin.
Purified
RUO
Antibody
Monoclonal
Human
Documents
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