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beta-3 Defensin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14216

Catalog No. PA14216


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Description

Description

PA1-4216 detects the beta-Defensin-3 protein from human samples. PA1-4216 has been successfully used in Western blot and immunohistochemistry procedures. The PA1-4216 immunogen is a synthetic peptide corresponding to residues G(23) I I N T L Q K Y Y C(33) of the 5 kDa human beta Defensin-3 protein.

A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and cloned from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomycin-resistant Enterococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.
Specifications

Specifications

beta-3 Defensin
Polyclonal
Unconjugated
DEFB103A
Liquid
DEFB103A
Synthetic peptide corresponding to residues G(23) I I N T L Q K Y Y C(33) of human beta Defensin-3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P81534
DEFB103, DEFB3, HBD-3, HBD3, HBP-3, HBP3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
414325
Documents
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