beta-3 Defensin Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14216
PA1-4216 detects the beta-Defensin-3 protein from human samples. PA1-4216 has been successfully used in Western blot and immunohistochemistry procedures. The PA1-4216 immunogen is a synthetic peptide corresponding to residues G(23) I I N T L Q K Y Y C(33) of the 5 kDa human beta Defensin-3 protein.A novel, nonhemolytic antimicrobial peptide (human beta-defensin-3, hBD-3) was isolated from human lesional psoriatic scales and cloned from keratinocytes. hBD-3 demonstrated a salt-insensitive broad spectrum of potent antimicrobial activity against many potentially pathogenic microbes including multiresistant S. aureus and vancomycin-resistant Enterococcus faecium. Keratinocytes and airway epithelial cells are cellular sources of hBD-3. Tumor necrosis factor alpha and contact with bacteria were found to induce hBD-3 mRNA expression. hBD-3 therefore might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.
|Synthetic peptide corresponding to residues G(23) I I N T L Q K Y Y C(33) of human beta Defensin-3.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|DEFB103, DEFB3, HBD-3, HBD3, HBP-3, HBP3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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