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MilliporeSigma™ anti-beta-Amyloid (1-42), Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC15025UG

Catalog No. PC15025UG


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Description

Description

Specifically detects β-Amyloid (1-42) Clone: in Human samples, and it is validated for Dot Blot, ELISA, Radioimmunoassay

A number of mutations, identified in the gene encoding theβ-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer's Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing ofβAPP, resulting in increased extracellular concentration ofβ-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of Aβ leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recognizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin andβAPP mutants while other studies have used Aβ specific antibodies to prevent thein vitro fibrillar aggregation of Aβ.
Specifications

Specifications

β-Amyloid (1-42)
Unconjugated
purified
a synthetic peptide corresponding to amino acids from a C-terminal fragment of human
25μg
−20°C
Polyclonal
Human
Dot Blot, ELISA, Radioimmunoassay
In phosphate buffer, pH 7.4.
Rabbit
IgG
RUO
Primary
Recognizes specifically β-amyloid peptide (1-42). Does not cross-react with β-amyloid peptide (1-40) or β-amyloid peptide (1-43). Antibody Target Gene Symbol: APP Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2 Entrez Gene Name: amyloid beta (A4) precursor protein
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