MilliporeSigma anti-beta-Amyloid (1-42), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC15025UG
Specifically detects β-Amyloid (1-42) Clone: in Human samples, and it is validated for Dot Blot, ELISA, RadioimmunoassayA number of mutations, identified in the gene encoding theβ-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimer's Disease. Mutations in the genes encoding presenilin 1 and presenilin 2 have also been shown to alter the processing ofβAPP, resulting in increased extracellular concentration ofβ-amyloid peptide Aβ1-42(43) relative to Aβ1-40. Biophysical and biochemical experiments suggest that Aβ1-42(43) may serve as a catalyst for the aggregation and deposition of Aβ leading to neurotoxic effects associated with senile plaque formation. Furthermore, antibodies recognizing Aβ1-42 revealed that the long form of the peptide is increased in presenilin andβAPP mutants while other studies have used Aβ specific antibodies to prevent thein vitro fibrillar aggregation of Aβ.
|a synthetic peptide corresponding to amino acids from a C-terminal fragment of human|
|Dot Blot, ELISA, Radioimmunoassay|
|In phosphate buffer, pH 7.4.|
|Recognizes specifically β-amyloid peptide (1-42). Does not cross-react with β-amyloid peptide (1-40) or β-amyloid peptide (1-43). Antibody Target Gene Symbol: APP Target Synonym: AAA, AD1, Adap, AL024401, Amyloid precursor, Amyloidogenic glycoprotein, APP isoform 1, APPI, appican, CTFgamma, CVAP, E030013M08RIK, Nexin II, P3, PN2, PreA4, PROTEASE NEXIN2 Entrez Gene Name: amyloid beta (A4) precursor protein|
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