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beta Arrestin 1 Rabbit anti-Bovine, Human, Mouse, Rat, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523342

Catalog No. PIPA523342


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Description

Description

Beta-arrestin 1 is a 418 amino acid containing signaling neurotransmitter that belongs to the arrestin family with an arrestin N terminal and an arrestin C terminal domain. A regulator of beta-adrenergic receptor function, Beta-arrestin 1 seems to bind to phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins. It is also reported to act as an activator of the lymphoid enhancer factor (LEF) transcription factor. Beta-arrestin 1 plays a crucial role in ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as an adaptor for the MDM2 E3 ligase. Purified beta-arrestin inhibits the signaling function of BARK-phosphorylated beta-adrenergic receptors by more than 75%, but not that of rhodopsin, and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most tissues.
Specifications

Specifications

beta Arrestin 1
Polyclonal
Unconjugated
ARRB1
Liquid
ARRB1
Synthetic peptide (334 LLGDLASSDVAVELPFT 350) of Beta-arrestin 1 protein.
Protein A
RUO
Antibody
Polyclonal
Bovine, Human, Mouse, Rat, Zebrafish
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P17870, P49407, Q8BWG8, P29066
ARB1, ARR1, arrestin 2, beta-arrestin-1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
109689, 25387, 281637, 408, 553266
Documents
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