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beta Synuclein Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118259

Catalog No. 01-670-512

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PA1-18259 detects beta Synuclein from human and rat samples. PA1-18259 has been successfully used in immunohistochemistry and Western blot procedures. The PA1-18259 immunogen is a synthetic peptide corresponding to residues I(108) E P L M E P E G S Y E D P P Q E(125) of human beta synuclein protein, conjugated to diphteria toxid. Reconstitute with 100 µL of distilled water.

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer′s (AD), Parkinson′s PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.


beta Synuclein
whole serum with no preservative
Q16143, Q63754
Human, Rat
Immunohistochemistry, Western Blot
Synthetic peptide corresponding to residues I(108) E P L M E P E G S Y E D P P Q E(125) of human beta synuclein protein.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
113893, 6620
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