beta Synuclein Sheep anti-Human, Rat, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA118260
PA1-18260 detects beta Synuclein from human and rat samples. PA1-18260 has been successfully used in immunohistochemistry procedures. The PA1-18260 immunogen is a synthetic peptide corresponding to residues I(108) E P L M E P E G S Y E D P P Q E(125) of human beta synuclein protein, conjugated to diphteria toxid. Reconstitute with 100 µL of distilled water.Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer ft.s (AD), Parkinson ft.s PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
|whole serum with no preservative|
|Synthetic peptide corresponding to residues I(108) E P L M E P E G S Y E D P P Q E(125) of human beta synuclein protein.|
|-20° C, Avoid Freeze/Thaw Cycles|