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beta Tubulin Mouse anti-Bovine, Human, Mouse, Rat, Clone: AA10, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen 480011

Catalog No. 48-001-1


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Description

Description

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintece. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules. Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.

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Specifications

Specifications

beta Tubulin
Monoclonal
Unconjugated
TUBB
Liquid
TUBB, Tubb1
Synthetic peptide corresponding to beta III tubulin
Protein G
RUO
Antibody
Monoclonal
Bovine, Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
AA10
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5
Q2KJD0, P07437, A2AQ07
tubulin, beta 3 class III, TUBB4, CFEOM3A, tubulin, beta 3, beta-4, CDCBM, Tubulin beta-4 chain, class III beta-tubulin, Tubulin beta-III, tubulin beta-3 chain
Mouse
IgG
100 μL
-20°C or -80°C if preferred
Primary
203068, 545486, 615087, 679312
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