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Bi-1 Mouse anti-Human, Clone: 20F248, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141678

Catalog No. 01-676-623


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Description

Description

MA1-41678 is derived from a mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human B1.  Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007).  BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli.  Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury.  Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.   
Specifications

Specifications

Bi-1
Monoclonal
1.0 mg/mL
PBS with 0.05% sodium azide
P55061
BAXI1, BI-1, TEGT
Mouse
IgM
0.1 mL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7009
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
20F248
Unconjugated
TMBIM6
Liquid
TMBIM6
A mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human Bax inhibitor 1.
IgM
RUO
Antibody
Monoclonal
Human
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