Bi-1 Mouse anti-Human, Mouse, Rat, Clone: 20F430, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA141108
Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.
|PBS with 0.2% gelatin and 0.05% sodium azide|
|P55061, Q9D2C7, P55062|
|BAXI1, BI-1, TEGT|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|110213, 24822, 7009|
|Synthetic peptides corresponding to the N-terminal, internal, and C-terminal regions of human B1.|
|Human, Mouse, Rat|
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