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BID Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19016

Catalog No. 01-674-600


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Description

Description

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
Specifications

Specifications

BID
Polyclonal
Unconjugated
BID
Liquid
BID
Synthetic peptide corresponding to the C terminus amino acids TYVRSLARNGMD.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P55957
BID; BH3 interacting domain death agonist ; HGNC:1050; MGC15319; MGC42355 ; BH3-interacting domain death agonist; Human BID coding sequence; apoptic d
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
637
Documents
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