BID Goat anti-Human, Polyclonal, Invitrogen™
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19016
DescriptionBID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
|Synthetic peptide corresponding to the C terminus amino acids TYVRSLARNGMD.|
|Antigen affinity chromatography|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|BID; BH3 interacting domain death agonist ; HGNC:1050; MGC15319; MGC42355 ; BH3-interacting domain death agonist; Human BID coding sequence; apoptic d|
|-20° C, Avoid Freeze/Thaw Cycles|
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