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BID Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511384

Catalog No. PIPA511384


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Description

Description

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
Specifications

Specifications

BID
Polyclonal
Unconjugated
BID
Liquid
BID
KLH conjugated synthetic peptide between 39-68 amino acids from mouse BID
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.45 mg/mL
PBS with 0.09% sodium azide
P55957, P70444
BH3-interacting domain death agonist; BID; p22 BID
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
12122, 637
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