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Bif1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520248

Catalog No. PIPA520248

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A suggested positive control is Hela cell lysate. PA5-20248 can be used with blocking peptide PEP-0370.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by the activation of proteolytic enzymes termed caspases. Proteins that comprise the Bcl-2 family such as Bax appear to control the activation of these enzymes. Bax activity was found to be regulated by its association with Bax-interacting factor 1 (BIF), a member of the endophilin B family that is associated with intracellular membranes. Following this interaction, Bax undergoes a conformational change and translocates to mitochondrial membranes. The Bax/BIF interaction appears to be enhanced by apoptotic stimuli, suggesting that BIF acts as the trigger to activate Bax, and as suppression of BIF promoted HeLa cell colony formation in soft agar, it may have a role in the suppression of cancer progression. At least two isoforms of BIF are known to exist.


100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
51100, 54673
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9Y371, Q9JK48
A 15 amino acid peptide from near the carboxy terminus of human BIF.
Antigen affinity chromatography
Human, Mouse
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