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Bim Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511385

Catalog No. PIPA511385

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with mouse based on sequence homology.

Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Specifications

Specifications

Bim
Polyclonal
PBS with 0.09% sodium azide
O43521
Bcl-2-like protein 11, Bcl2 interacting mediator of cell death
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
10018
Immunohistochemistry, Western Blot
Unconjugated
BCL2L11
Liquid
BCL2L11
KLH conjugated synthetic peptide between 130-165 amino acids from human Bim BH3 Domain
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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