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BMI-1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512197

Catalog No. PIPA512197

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

This antibody is predicted to react with bovine, chicken and mouse based on sequence homology.

BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A  ft.Lys-119 ft., rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.
Specifications

Specifications

BMI-1
Polyclonal
PBS with 0.09% sodium azide
P35226
Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4, RNF51
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
648
Immunohistochemistry, Western Blot
Unconjugated
BMI1
Liquid
BMI1
KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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