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BMI-1 Rabbit anti-Human, Mouse, DyLight® 550, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522848

Catalog No. PIPA522848


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Description

Description

Suggested positive control: human and mouse skeletal muscle.

The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells ft. ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.
Specifications

Specifications

BMI-1
Polyclonal
DyLight™ 550
BMI1
Liquid
BMI1
A synthetic peptide made to an internal region (within residues 1-100) of the human Bmi1 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1.09 mg/mL
sodium borate with no preservative
P35226, P25916
RP11-573G6.1, FLVI2/BMI1, PCGF4, RNF51, B lymphoma Mo-MLV insertion region 1 homolog, flvi-2/bmi-1, murine leukemia viral (bmi-1) oncogene homolog, polycomb complex protein BMI-1, polycomb group RING finger protein 4, polycomb group protein Bmi1, ring finger protein 51
Rabbit
IgG
100 μL
4° C, store in dark
Primary
12151, 648
Documents
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