BMI-1, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA116973

Catalog No. 01-670-219

Description

The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.

Suggested positive control: human and mouse skeletal muscle, human skeletal muscle protein, antigen standard for BMI1 (transient overexpression lysate), mouse skeletal muscle protein.

Specifications

• Antigen: BMI-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BMI1
• Gene Alias: Pcgf4 antibody, Polycomb complex protein BMI-1 antibody, Polycomb group RING finger protein 4 antibody
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12151, 648
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Concentration: 1.09mg/mL
• Formulation: tris glycine with 0.15M NaCl and 0.05% sodium azide
• Gene Accession No.: P35226, P25916
• Gene Symbols: BMI1
• Immunogen: Synthetic peptide corresponding to an internal region within residues 1-100 of human Bmi1 [Swiss-Prot# P35226] .
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG