BMI-1, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA116973
The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells.Suggested positive control: human and mouse skeletal muscle, human skeletal muscle protein, antigen standard for BMI1 (transient overexpression lysate), mouse skeletal muscle protein.
|Synthetic peptide corresponding to an internal region within residues 1-100 of human Bmi1 [Swiss-Prot# P35226] .|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|tris glycine with 0.15M NaCl and 0.05% sodium azide|
|Pcgf4 antibody, Polycomb complex protein BMI-1 antibody, Polycomb group RING finger protein 4 antibody|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles., Store at -20°C, avoiding freeze/thaw cycles.|
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