MilliporeSigma™ anti-BMPR2 Clone: 4A2,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ ST1717100UG

Catalog No. ST1717100UG

Description

Specifically detects BMPR2 Clone: 4A2 in Human samples, and it is validated for ELISA

BMPR2 a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-β superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

Specifications

• Antigen: BMPR2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Purified

• Applications: ELISA
• Clone: 4A2
• Formulation: In PBS, pH 7.2.
• Immunogen: A recombinant polypeptide corresponding to amino acids of 939-1037 human BMPR2, expressed as a GST fusion protein.
• Regulatory Status: RUO
• Test Specificity: Recognizes the BMPR2 protein.
• Content And Storage: −20°C
• Isotype: IgG2a

For Research Use Only