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MilliporeSigma anti-BMPR2 Clone: 4A2,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma ST1717100UG
Specifically detects BMPR2 Clone: 4A2 in Human samples, and it is validated for ELISABMPR2 a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-β superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
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|In PBS, pH 7.2.|
|Recognizes the BMPR2 protein.|
|A recombinant polypeptide corresponding to amino acids of 939-1037 human BMPR2, expressed as a GST fusion protein.|
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