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MilliporeSigma™ anti-BMPR2 Clone: 4A2, Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  MilliporeSigma™ ST1717100UG

Catalog No. ST1717100UG



Description

Description

Specifically detects BMPR2 Clone: 4A2 in Human samples, and it is validated for ELISA

BMPR2 a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-β superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

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Specifications

Specifications

BMPR2
4A2
In PBS, pH 7.2.
Murine
IgG2a
RUO
Primary
Recognizes the BMPR2 protein.
ELISA
Unconjugated
Purified
A recombinant polypeptide corresponding to amino acids of 939-1037 human BMPR2, expressed as a GST fusion protein.
100μg
−20°C
Monoclonal
Human
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