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BRSK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520352

Catalog No. PIPA520352


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-20352 can be used with blocking peptide PEP-0472.

BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.
Specifications

Specifications

BRSK1
Polyclonal
Unconjugated
BRSK1
Liquid
BRSK1
a 28 amino acid peptide from near the carboxy terminus of human BRSK1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8TDC3, Q5RJI5, B2DD29
hSAD1; BR serine/threonine-protein kinase 1; SAD1 homolog; SAD1 kinase; SadB kinase short isoform; brain-selective kinase 1; brain-specific serine/threonine-protein kinase 1; protein kinase SAD1A; serine/threonine-protein kinase BRSK1; serine/threonine-protein kinase SAD-B; synapses of Amphids Defective homolog 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
381979, 499073, 84446
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