ABCB11 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527742
PA5-27742 targets BSEP in ICC/IF, IHC (P) and WB applications and shows reactivity with Human samples. The PA5-27742 immunogen is recombit fragment corresponding to a region within amino acids 474 and 745 of Human BSEP. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
|Recombit fragment corresponding to a region within amino acids 474 and 745 of Human BSEP|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP, ABC member 16, MDR/TAP subfamily, ATP-binding cassette sub-family B member 11, bile salt export pump, progressive familial intrahepatic cholestasis 2, sister p-glycoprotein|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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