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Btk Mouse anti-Human, Unlabeled, Clone: 53/BTK, BD

Mouse Monoclonal Antibody

$225.00 - $445.00

Specifications

Antigen Btk
Isotype IgG2a
Immunogen Human N-Terminal Btk aa. 2-172 Recombinant Protein
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611117
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BD Biosciences
611117
150μg Each for $445.00
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BDB611116
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BD Biosciences
611116
50μg Each for $225.00
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Description

Description

Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase whose function is critical for proper B cell development and signaling. It is a member of the Tec family of kinases which includes Tec and Itk. In addition to an N-terminal pleckstrin homology (PH) domain, the Tec proteins contain Src homology domains 2 and 3 (SH2 and SH3) and a stretch of 60-80 amino acids between the PH and SH3 domains termed the Tec homology domain. The activity of Btk is regulated by Src-mediated phosphorylation of the kinase domain at tyrosine 551. This event induces Btk kinase activity and subsequent autophosphorylation at tyrosine 223 in the SH3 domain. Phosphorylated Btk then associates with the cell membrane via the interaction of the PH domain with phosphatidylinositol 3, 4, 5-triphosphate. The PH domain is essential for proper activation and function of Btk. A mutation in the PH domain results in Xid, murine X-linked immunodeficiency, and human X-linked agammaglobulinemia.

Host Species: Mouse
Clone: 53
Isotype: IgG2a
Species Reactivity: Human
Immunogen: Human N-Terminal Btk aa. 2-172 Recombinant Protein
Formula Weight [Chemical]: 77kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Btk
Human N-Terminal Btk aa. 2-172 Recombinant Protein
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG2a
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
53/BTK
250μg/mL

For Research Use Only.

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