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Bub1 Mouse anti-Human, Clone: 14H5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA15755

Catalog No. 01-675-175


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Description

Description

MA1-5755 detects BUB1 in human samples. MA1-5755 has been successfully used in immunofluorescence and immunoprecipitation procedures.

Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to maligt transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Specifications

Specifications

BUB1
Monoclonal
1.1 mg/mL
PBS with 0.1% sodium azide
O43683
BUB1A, BUB1L, hBUB1
Mouse
IgG1, kappa
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
699
Immunocytochemistry, Immunofluorescence, Immunoprecipitation
14H5
Unconjugated
BUB1
Liquid
BUB1
Recombit human BUB1CFA from SP2/0 cells
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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