Bub1 Mouse anti-Human, Clone: 14H5, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA15755
MA1-5755 detects BUB1 in human samples. MA1-5755 has been successfully used in immunofluorescence and immunoprecipitation procedures.Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to maligt transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
|PBS with 0.1% sodium azide|
|BUB1A, BUB1L, hBUB1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation|
|Recombit human BUB1CFA from SP2/0 cells|
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