BUB1B Polyclonal Antibody, Invitrogen
BUB1B Antibody, PA1-12551, from Invitrogen. Species Reactivity: Mouse; Applications: Immunohistochemistry, Western Blot.
Manufacturer: Invitrogen PA112551
BUB1B Antibody, PA1-12551, from Invitrogen. Species Reactivity: Mouse; Applications: Immunohistochemistry, Western Blot.Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
Host Species: Sheep
Cross Reactivity: Mouse
Immunogen: Recombinant protein corresponding to residues 883-1052 of mouse Bub1b.
Formulation: 250µg purified antibody (1mg/mL) in PBS and 0.08% sodium azide
Synonyms: BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
Uniprot Accession: Q9Z1S0
Entrez GeneID: 12236
Gene Symbol: BUB1B
A suggested positive control for this product is mitotic NIH-3T3 cells.
|Recombinant protein corresponding to residues 883-1052 of mouse Bub1b.|
|Avoid Freeze/Thaw Cycles|
|250μg purified antibody (1mg/mL) in PBS and 0.08% sodium azide|
|BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1|
Purchase any three Invitrogen™ Antibodies and receive a fourth antibody at no additional cost. This is an NLSU exclusive offer. You must apply and qualify for the program to be eligible.
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok