anti-BUB1B Polyclonal, Thermo Scientific™

BUB1B Polyclonal antibody PA1-12551 from Thermo Scientific™ specifically detects BUB1B in Mouse samples, and it is validated for Immunohistochemistry and Western Blot

Manufacturer: Thermo Scientific PA112552

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Catalog No. 01-674-791

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    Specifications

    Antigen BUB1B
    Applications Immunohistochemistry,Western Blotting
    Conjugate Unlabeled
    Cross Reactivity Mouse
    Format Purified
    Formulation 250μg purified Antibody in PBS, with 0.08% sodium azide;
    Gene Accession No. Q9Z1S0
    Gene Alias BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
    Gene Symbols Bub1b
    Host Species Sheep
    Immunogen Recombinant protein corresponding to residues 10-190 of mouse Bub1b.
    Isotype IgG
    Quantity 250μg
    Species Reactivity Mouse
    Storage Requirements Avoid Freeze/Thaw Cycles
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal
    Gene ID (Entrez) 12236

    BUB1B Polyclonal antibody PA1-12551 from Thermo Scientific™ specifically detects BUB1B in Mouse samples, and it is validated for Immunohistochemistry and Western Blot

    Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
    Host Species: Sheep
    Cross Reactivity: Mouse
    Isotype: IgG
    Immunogen: Recombinant protein corresponding to residues 10-190 of mouse Bub1b.
    Formulation: 250µg Purified Antibody in PBS, with 0.08% sodium azide
    Synonyms: BUB1beta, BUBR1, MAD3L, SSK1, hBUBR1
    Uniprot Accession: Q9Z1S0
    Entrez GeneID: 12236
    Gene Symbol: Bub1b
    A suggested positive control for this product is mitotic NIH-3T3 cells.

  • Description & Specifications

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