Bub3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520388
A suggested positive control is Jurkat cell lysate. PA5-20388 can be used with blocking peptide PEP-0505.The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.
|A 16 amino acid peptide from near the carboxy terminus of human bub3.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|BUB3L, hBUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog; budding uninhibited by benomyl; mitotic checkpoint component; mitotic checkpoint protein BUB3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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