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Bub3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520388

Catalog No. PIPA520388


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-20388 can be used with blocking peptide PEP-0505.

The mitotic checkpoint protein Bub3 is involved with the essential spindle checkpoint pathway which operates during early embryogenesis. Bub3 is important during G2 and early mitosis stages, permitting entry into mitosis depending upon the assembly state of microtubules, thus preventing premature sister chromatid separation, mis-segregation and aneuploidy. Bub3 contains four WD repeat domains and is required for the kinetochore localization of Bub1, a related kinase that is necessary for spindle assembly checkpoint function. Bub1 is able to autophosphorylate and can catalyze the phosphorylation of Bub3. Both Bub1 and Bub3 are mutually dependent for function. Altered Bub expression levels may significantly impair mitotic checkpoint function and is associated with tumor cell proliferation.
Specifications

Specifications

Bub3
Polyclonal
Unconjugated
BUB3
Liquid
BUB3
A 16 amino acid peptide from near the carboxy terminus of human bub3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O43684, Q9WVA3
BUB3L, hBUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog; budding uninhibited by benomyl; mitotic checkpoint component; mitotic checkpoint protein BUB3
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
12237, 9184
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