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ETS1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141414

Catalog No. 01-675-543


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Description

Description

Suggested positive control: Jurkat, antigen standard for ETS1 (transient overexpression lysate), Jurkat whole cell lysate.

Principal Names: c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54; Official Gene Symbol: ETS1 Gene ID:  2113 (Human) Gene Map Locus: 11q23.3 (Human)  ETS1, a 441 A.A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependant IL-5 expression. 
Specifications

Specifications

ETS1
Polyclonal
Unconjugated
ETS1
Liquid
ETS1
Human c-Ets-1.
Protein G
RUO
Antibody
Polyclonal
Human
Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P14921
ETS1, c-ets-1
Rabbit
IgG
200 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
2113
Documents
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