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c-Raf Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA520970

Catalog No. PIPA520970


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Description

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20970 can be used with blocking peptide PEP-1084.

C-raf is the cellular homolog of viral raf gene (v-raf) and encodes a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases. Once activated, C-raf phosphorylates and activates the protein kinases MEK1 and MEK2, which in turn phosphorylate and activate the serine/threonine specific protein kinases, ERK1 and ERK2. These activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noo syndrome 5 and LEOPARD syndrome 2.
Specifications

Specifications

C-raf
Polyclonal
Unconjugated
RAF1
Liquid
RAF1
an 19 amino acid peptide near the amino terminus of human C-raf.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P04049, Q99N57, P11345
CRAF, NS5, Raf-1, c-Raf; Oncogene RAF1; RAF proto-oncogene serine/threonine-protein kinase; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase
Chicken
IgY
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
110157, 24703, 5894
Documents
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