c-Raf Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Chicken Polyclonal Antibody
Manufacturer: Invitrogen PA520970
A suggested positive control is NIH-3T3 cell lysate. PA5-20970 can be used with blocking peptide PEP-1084.C-raf is the cellular homolog of viral raf gene (v-raf) and encodes a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases. Once activated, C-raf phosphorylates and activates the protein kinases MEK1 and MEK2, which in turn phosphorylate and activate the serine/threonine specific protein kinases, ERK1 and ERK2. These activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noo syndrome 5 and LEOPARD syndrome 2.
|an 19 amino acid peptide near the amino terminus of human C-raf.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|P04049, Q99N57, P11345|
|CRAF, NS5, Raf-1, c-Raf; Oncogene RAF1; RAF proto-oncogene serine/threonine-protein kinase; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|110157, 24703, 5894|
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